Over the years, companies have adopted hiring algorithms because they promise wider job candidate pools, lower recruitment costs and less human bias. Despite these promises, they also bring perils. Using them can inflict unintentional harms on individual human rights. These include the five human rights to work, equality and nondiscrimination, privacy, free expression and free association. Despite the human rights harms of hiring algorithms, the AI ethics literature has predominantly focused on abstract ethical principles. This is problematic for two reasons. (...) First, AI principles have been criticized for being vague and not actionable. Second, the use of vague ethical principles to discuss algorithmic risks does not provide any accountability. This lack of accountability creates an algorithmic accountability gap. Closing this gap is crucial because, without accountability, the use of hiring algorithms can lead to discrimination and unequal access to employment opportunities. This paper makes two contributions to the AI ethics literature. First, it frames the ethical risks of hiring algorithms using international human rights law as a universal standard for determining algorithmic accountability. Second, it evaluates four types of algorithmic impact assessments in terms of how effectively they address the five human rights of job applicants implicated in hiring algorithms. It determines which of the assessments can help companies audit their hiring algorithms and close the algorithmic accountability gap. (shrink)

Abstract: Michael Tooley’s Comments on James Sterba’s Book, Is a Good God Logically Possible? -/- My comments on Jim Sterba’s book, Is a Good God Logically Possible?, were divided into the following sections. In the first section, I listed some of the attractive features of Sterba’s discussion. These included, first of all, his use of the ideas of “morally constrained freedom” and “constrained intervention by God” to show the moral evils in our world cannot be justified by an appeal (...) to the idea of free will. Then secondly, there is his response to the claim that if God intervened to prevent horrendous evils, one would have a world without regularities. Thirdly, there are his responses to certain important religiously based attempts to answer arguments from evil, namely, those that appeal to either Christian or Jewish views that we have wronged God, and stand in need of redemption, along with his discussion, and criticism of, certain specific, central Christian doctrines. Fourthly, there are his criticisms, first, of the four solutions that Michael Murray offers for the problem posed by the suffering of non-human animals, and then, secondly, of Trent Dougherty’s use of “a version of John Hick’s theodicy of soul-making in an attempt to provide a God-justifying account of animal suffering” (Dougherty, The Problem of Animal Pain: A Theodicy For All Creatures Great And Small, 2014). -/- I then went on to offer critical comments on various aspects of Sterba’s discussion, where I discussed: (1) his negative view of the relevance of probabilistic epistemology to the problem of evil; (2) his failure, in attempting to rule out logical connections between goods and evil, to consider evils that are not moral evils, such as Peter van Inwagen’s claim that “Being massively irregular is a defect in a world, a defect at least as great as the defect of containing patterns of suffering mentally equivalent to those found in the actual world”; (3) his failure, in discussing Michael Bergmann’s skeptical theism, to point out the central weakness in the principles that Bergmann advances, namely, that they entail not only moral skepticism, but inductive skepticism as well; (4) his treatment of natural evils, where he mistakenly claims that, in contrast to the case of horrendous moral evils, all of which God could prevent, God could not eliminate all horrendous natural evils, and where he says noting about either the horrendous evils due to bacteria and viruses or those due to natural disasters, all of which could be prevented by an omnipotent and omniscient deity without our ever being aware that this was happening. -/- Finally, I concluded by raising the question of what the strongest way is of formulating a logical incompatibility argument from evil, and I argued that it should take the form of the argument I set out in The Problem of Evil (2019) so that first, it should be based on natural evils rather than on moral evils; secondly, that it should focus on the case of suffering endured by sentient non-persons; and thirdly, that a crucial part must be an argument restricting the logical connections between goods and evils, an argument based on the proposition that the only goods and evils that can exist involve properties of, and relations between, conscious beings. -/- . (shrink)

In _Beyond Animal Rights_, Josephine Donovan and Carol J. Adams introduced feminist "ethic of care" theory into philosophical discussions of the treatment of animals. In this new volume, seven essays from _Beyond Animal Rights_ are joined by nine new articles-most of which were written in response to that book-and a new introduction that situates feminist animal care theory within feminist theory and the larger debate over animal rights. Contributors critique theorists' reliance on natural rights doctrine and utilitarianism, which, they (...) suggest, have a masculine bias. They argue for ethical attentiveness and sympathy in our relationships with animals and propose a link between the continuing subjugation of women and the human domination of nature. Beginning with the earliest articulation of the idea in the mid-1980s and continuing to the theory's most recent revisions, this volume presents the most complete portrait of the evolution of the feminist-care tradition. (shrink)

Laffin, Josephine On 31 October 2017 it will be five hundred years since Martin Luther posted his Ninety-Five Theses on the door of the Castle Church in Wittenberg, the date traditionally hailed as the start of the Lutheran Reformation. Another anniversary is a personal one: it is twenty-five years since I began teaching Reformation history. It seems an appropriate time, therefore, to pause and reflect on the significance of this task.

L’Union européenne nous invite à repenser les conditions et les attributs de la souveraineté traditionnellement rattachée aux États-nations. Dans cet article, est proposée une tentative de re-conceptualisation à partir des différentes définitions de la souveraineté, et de l’analyse d’un exemple : celui de la politique étrangère et de l’exercice diplomatique de l’Union européenne. En effet, la souveraineté possède toujours deux faces : une face interne qui se charge de définir la loi, le droit, et de les faire appliquer sur un (...) territoire délimité ; une face externe qui exporte et affirme les intérêts, les valeurs et les principes qui prévalent en interne. La politique étrangère et son outil principal qu’est l’action diplomatique, consistent dans l’expression vers l’extérieur de la souveraineté d’un corps politique. Nous nous interrogerons ainsi sur la nature de la souveraineté incarnée par l’Union européenne. (shrink)

The main goal of Michael Tooley’s groundbreaking book is to establish a position intermediate between the tenseless theory of time and the standard tensed theory of time. Tooley argues for a novel version of the tensed theory of time, namely, that the future is unreal and the present and past real, and yet that reality consists only of tenseless facts. The question that naturally arises for the reader concerns an apparent paradox: how could the tensed theory of time (...) be true if reality consists only of tenseless facts? (shrink)

Résumé Dans les situations sociomotrices, l’engagement des participants n’est pas seulement réductible aux communications directes. Il est surtout lié à l’émergence de systèmes de signes assurant la dynamique globale du jeu. Nous proposons d’appréhender la communication comme un système d’interaction global constitué de plusieurs canaux. On y retrouve les communications directes mais aussi quatre systèmes de signes : celui des praxèmes, des gestèmes, des gestes et des communications verbales. Ce travail interroge la place de chaque canal communicationnel dans deux sports (...) et deux jeux traditionnels. Nous recrutons trois groupes de 20 étudiants pour participer aux jeux mentionnés. Les communications sont filmées, décryptées, triées et catégorisées. On constate une forte prévalence des praxèmes dans les sports collectifs, tandis que la répartition des communications est plus équilibrée dans les jeux traditionnels. La quantité, la variabilité et l’organisation des signes sont sensibles à la logique interne. Globalement, cette recherche tend à montrer que les jeux sont un formidable laboratoire in vivo pour comprendre l’organisation des systèmes de signes. Spécifiquement, elle apporte des informations sur le pouvoir socialisant de la sémiotricité de chaque jeu et sur le renouvellement des pédagogies qu’elle peut engendrer. (shrink)

Decoding Abortion Rhetoric: Communicating Social Change. By Celeste Michelle Condit.

Comment: This translation contains a correction of an argument in the original English edition, a correction that was subsequently made in the 1999 English Paperback edition, The correction is described below in the final paragraph. Differences in language can seriously restrict one's access to, and knowledge of, the philosophical work that's being done in other countries, and before the publication in 1997 of my book Time, Tense, and Causation, I was not aware of the depth of interest, in Italy, in (...) analytical philosophy in general, and metaphysics in particular. Since that time, however, I've had the opportunity of talking to, and corresponding with, Italian philosophers who are currently working very intensely on problems in the philosophy of time. I very much enjoyed those discussions, and so I'm very pleased indeed that my book has now been translated into Italian. -/- The introduction to the book will provide readers with quite a detailed overview of my approach to the philosophy of time, and of the main theses that I am defending. But perhaps it will be helpful here if I try to sketch, very briefly, the big picture. -/- The central issue in the philosophy of time concerns the choice between tensed and tenseless accounts of the nature of time – or, as I prefer to express it, between dynamic and static conceptions of reality. According to tensed (or dynamic) accounts, there are significant ontological differences between the past, the present, and the future – either because the world contains intrinsic tensed properties of passiveness, presentness, and futurity, or else because the past, the present, and the future are not all equally real. In contrast, according to tenseless (or static) views of the nature of time, there are no intrinsic tensed properties, and the past, the present, and the future are all equally real. In this book, I defend a dynamic view of time dash specifically, one according to which, while the past and the present are now real, the future is not. This view has, of course, a very long history, with a version of it having been defended by Aristotle in his famous discussion of the sea battle tomorrow, in which he argued that, although it is now true – indeed necessarily so – that either there will be a sea battle tomorrow or there will not be one, it is not now true that there will be a sea battle tomorrow, and not now true that there will not be one. Only when tomorrow comes will the world contain states of affairs that make one of these propositions true, and the other false. -/- But while this general view of the nature of time has a very long and distinguished history – and also seems, intuitively, quite appealing – it has become clear, especially in this century, that it is exposed to very strong objections – objections moreover, that come not merely from philosophy, but also from contemporary physics, and especially from Einstein's special theory of relativity. One of the main challenges accordingly, for any defense of a tensed or dynamic view of time, is to show that those objections can be answered. -/- In grappling with those objections, however, one thing that emerged very clearly was that some theses that defenders of tensed approaches to time have traditionally viewed as absolutely essential must be abandoned as unsound. The result is that. I was led to a view of the nature of time that is, in many respects, intermediate between tenseless views of time and traditional tensed approaches. In particular, advocates of traditional tensed views almost always maintain that the simplest temporal facts are themselves inherently tensed: they consist of facts such as, for example, that is certain apple is now red. But I maintain that, on the contrary, the simplest temporal facts, rather than being intrinsically tensed, are facts to the effect, for example, that a certain apple is now red at time t. On this fundamental issue, then, I agree with those who accept a tenseless or static view of time, since they too hold that the simplest tensed facts ¬– and indeed all tensed facts – are not tensed facts. How, then, does my approach to the nature time differ from a tenseless or static approach? The answer is that I also maintain that, although basic tensed facts are not inherently tensed, the world is nevertheless a dynamic one, since every present moment is a point at which things come into existence. Events, therefore, are not merely actual or nonactual – as is maintained by advocates of tenseless approaches to time. Rather an event is actual as of some time, and not actual as of other times. One needs, therefore, a temporally indexed notion of actuality, according to which an event is not actual until the time at which it occurs, and given that notion, one can explain, in a straightforward fashion, what it is for events to lie in the past, the present, and the future, and in the way that entails that the past and the present are real, but the future is not. -/- One task, as I have said, is to show that the many objections that have been advanced against dynamic conceptions of the world dash by philosophers – such as McTaggart, Quine, Smart, Putnam, and Mellor – can be answered. But even if, as I claim, this can be done, one is still left, of course, with the question of what positive reason there is, if any, for accepting a tensed or dynamic view of the world. -/- The argument that I develop in response to this question centers upon the concept of causation, and here I argue, first, that there are decisive objections to reductionist approaches to causation; secondly, that it is possible to set out a very plausible realistic account of the nature of causation; and, thirdly, that the crucial postulates that are involved in that account can only be satisfied in a dynamic world – indeed only in a dynamic world in which the past and the present are real, but the future is not. -/- This way of defending the view that our world is a dynamic one also has implications for some other issues – in particular, issues connected with the subtle and very difficult metaphysical question of the relation between time and causation. Thus, after setting out the above argument, I attempt to show that if causation can exist only in a dynamic world, then one can both demonstrate that backward causation is logically impossible and defend the view that the direction of time is to be defined in terms of the direction of causation, rather than vice versa. -/- Finally, a comment on the text. It involves one major change from the original English edition – namely in sections 4. 6.2 and 4.7. The change in those sections involves the crucial part in my argument both for the claim that our world is one where the past and present are real, but the future is not, and for the claim that backward causation is logically impossible. It was pointed out to me by Kenji Murota, a graduate student of philosophy at Keio University, that there was a problem in my original formulation of that argument. I'm grateful to him for his incisive criticism, and I'm pleased that I've had the opportunity of correcting that argument in the present edition. (shrink)

This paper describes the exploratory study which was carried out in Zimbabwe with an elementary Grade 7 class and with the firstand third- year student teachers, at a Teacher Training College, "doing philosophy", using Lipman's PIXIE and HARRY novels, respectively, and the proposed critical inquiry methodology.Secondly the perceptions of the participants, about their experiences during these exploratory sessions, which were derived from the researcher's self-evaluation and the students' informal evaluations, are presented in the paper.

Is belief in God epistemically justified? That's the question at the heart of this volume in the Great Debates in Philosophy series, with Alvin Plantinga and Michael Tooley each addressing this fundamental question with distinctive arguments from opposing perspectives. The first half of the book contains each philosopher's explanation of his particular view; the second half allows them to directly respond to each other's arguments, in a lively and engaging conversation Offers the reader a one of a kind, interactive (...) discussion Forms part of the acclaimed Great Debates in Philosophy series. (shrink)

In his article, ‘What's Wrong with Tooley's Argument from Evil?’, Calum Miller's goal was to show that the evidential argument from evil that I have advanced is unsound, and in support of that claim, Miller set out three main objections. First, he argued that I had failed to recognize that the actual occurrence of an event can by itself, at least in principle, constitute good evidence that it was not morally wrong for God to allow events of the kind (...) in question. Miller's second objection was then that, in attempting to show that it is unlikely that God exists, I had failed to consider either positive arguments in support of the existence of God or possible theodicies, and thus that I was unjustified in drawing any conclusions concerning the probability that theism is true in the light of the total evidence available. Miller's third and final objection was that one of the approaches to logical probability that I employed – namely, that based upon a structure-description equiprobability principle, rather than a state-description equiprobability principle – was unsound since it has clearly unacceptable implications. In response, I argue that all three of Miller's objections are unsound. The third objection, however, is nevertheless important since it shows that my type of argument from evil cannot be based merely on the evils found in the world. One must also consider good states of affairs, and their relations to bad ones. I show, however, that that deficiency can be addressed in a completely satisfactory manner. (shrink)

Michael Tooley presents a major new philosophical theory of the nature of time, offering a powerful alternative to the traditional "tensed" and recent "tenseless" accounts of time. He argues for a dynamic conception of the universe, in which past, present, and future are not merely subjective features of experience. He claims that the past and the present are real, while the future is not. Tooley's approach accounts for time in terms of causation. He therefore claims that the key (...) to understanding the dynamic nature of the universe is to understand the nature of causation. Time, Tense, and Causation is a landmark treatment of one of the oldest and most perplexing intellectual problems, and will be fascinating reading for anyone interested in the character of time. (shrink)

In a project The Hastings Center is now running on the future of prenatal testing, we are encountering clear examples, both in established law and in the practices of individual providers, of failures to respect women's reproductive autonomy: when testing is not offered to certain demographics of women, for instance, or when the choices of women to terminate or continue pregnancies are prohibited or otherwise not supported. But this project also raises puzzles for reproductive autonomy. We have learned that some (...) clinicians and patients do not discuss the fact that prenatal testing can lead to a decision about whether to terminate a pregnancy—they just don't talk about it. And while the decision whether to agree to prenatal screening and diagnostic testing is to be made with women's free and informed consent, many screening tests have been routinized in such a way that some women do not even recall agreeing to testing, while others feel that agreeing to testing is what their clinicians expect of them or that the testing is necessary to protect themselves and their families from the significant financial hardship of raising a child with a disability. In the face of these pressures, can one really say that women are freely choosing to undergo testing or are freely choosing to continue or terminate a pregnancy following receipt of test results? The reality of these pressures is requiring us to consider expanding the scope of our investigation beyond the clinical encounter to the broader context—to think harder about what reproductive autonomy means and how best to enhance it. (shrink)

This chapter contains sections titled: Basic Moral Principles and the Concept of a Person Human Persons and Human Organisms The Concept of a Person and the Wrongness of Killing What Makes Something a Person? Is Personhood a Matter of Degree? Is Potential Personhood Morally Significant? Is Species Membership Morally Significant? The Moral Status of Human Embryos, Fetuses, and Newborn Infants Summing Up: Ethics and the Concept of a Person References.

Basic Questions The following are among the basic questions discussed in this essay: (1) What is the concept of a person? (2) What properties make something a person? (3) Is personhood a matter of degree? (4) Is potential personhood morally significant? (5) Is species membership morally significant? (6) Why is the concept of a person important? Important Arguments The important arguments that are examined include the following: (1) Counterexample arguments: (a) Whole brain death and upper brain death. (b) Brain transplants. (...) (c) Currently irreparable damage versus impossibility of resuscitation. (2) The reprogramming argument. (3) The generalized potentialities argument. (4) Potentialities and comas: active versus passive. (5) Anti-speciesism and the common sense generality of the concept of a person: deities, angels, disembodied souls, extraterrestrials. Important Positions Among the important positions considered are the following: (1) Consciousness is sufficient for personhood. (2) Self-consciousness is necessary for personhood. (3) The capacity for thought is necessary for personhood. (4) Moral agency is necessary for personhood. (shrink)

Book reviewed in this article: Abortion and Infanticide. By Michael Tooley.

Contains eight contributions which extend feminist ethic-of-care theory to the issue of animal well-being. As a group, the essays aim to suggest ways that theorists can move beyond the notion of animal rights to establish care as a basis for the ethical treatment of animals. Annotation c. by Book.

Background There is now rising consensus that community engagement is ethically and scientifically essential for all types of health research. Yet debate continues about the moral aims, methods and appropriate timing in the research cycle for community engagement to occur, and whether the answer should vary between different types of health research. Co-design and collaborative partnership approaches that involve engagement during priority-setting, for example, are common in many forms of applied health research but are not regular practice in biomedical research. (...) In this study, we empirically examine the normative question: should communities be engaged when setting priorities for biomedical research projects, and, if so, how and for what purpose? Methods We conducted in-depth interviews with 31 members of the biomedical research community from the UK, Australia, and African countries who had engaged communities in their work. Interview data were thematically analysed. Results Our study shows that biomedical researchers and community engagement experts strongly support engagement in biomedical research priority-setting, except under certain circumstances where it may be harmful to communities. However, they gave two distinct responses on what ethical purpose it should serve—either empowerment or instrumental goals—and their perspectives on how it should achieve those goals also varied. Three engagement approaches were suggested: community-initiated, synergistic, and consultative. Pre-engagement essentials and barriers to meaningful engagement in biomedical research priority-setting are also reported. Conclusions This study offers initial evidence that meaningful engagement in priority-setting should potentially be defined slightly differently for biomedical research relative to certain types of applied health research and that engagement practice in biomedical research should not be dominated by instrumental goals and approaches, as is presently the case. (shrink)

Animals, Mind, and Matter challenges the current ascription of object status to animals in the law, commerce, and science, where they are conceived as property and commodities. Instead, Donovan establishes that animals are living subjects, have minds and opinions, and care about what happens to them.

Examining Henri Bergson's work, philosophy, and the body, this volume explores the history and philosophy of comedy, film, psychoanalysis and the comic performance of the future, creating a theoretical and practice-based framework for the field.

In this essay, I set out my responses to the following five questions that had been posed: -/- 1. Why were you initially drawn to metaphysics (and what keeps you interested)? 2. What do you consider to be your most important contributions to metaphysics? 3. What do you consider to be the proper method for metaphysics? 4. What do you think is the proper role of metaphysics in relation to other areas of philosophy and other academic disciplines, including the natural (...) sciences? 5. What do you consider to be the most neglected topics in contemporary metaphysics, and what direction would you like metaphysics to take in the future? (shrink)

In this essay, I set out my responses. to the following five questions that had been posed: -/- 1. What initially drew you to theorizing about science and religion? 2. Do you think science and religion are compatible when it comes to understanding cosmology (the origin of the universe), biology (the origin of life and of the human species), ethics, and/or the human mind (minds, brains, souls, and free will) 3. Some theorists maintain that science and religion occupy non-overlapping magisteria—i.e., (...) that science and religion each have a legitimate magisterium, or domain of teaching authority, and these two domains do not overlap. Do you agree? 4. What do you consider to be your own most important contribution(s) to theorizing about science and religion? 5. What are the most important open questions, problems, or challenges confronting the relationship between science and religion, and what are the prospects for progress? My responses to four of the questions were quite brief, with about three-quarters of what I said devoted to the second question, where I talked about cosmology, biology, psychology and the human mind, and ethics, and where I argued that in all of those areas there are very serious incompatibilities between science and/or philosophy on the one hand and Christianity on the other. (shrink)

Knowledge of God takes the form of a debate between Alvin Plantinga and Michael Tooley. Plantinga opens the batting with a seventy-page laying out of his case ‘that theism has a significant epistemic virtue: if it is true, it is warranted; this is a virtue naturalism emphatically lacks’. Indeed, Plantinga argues that ‘if naturalism were true, there would be no such thing as knowledge’. It will be recalled [e.g. Plantinga and Plantinga ] that Plantinga's position is that warrant, understood (...) as whatever it is that needs to be added to true belief to …. (shrink)

The authors aim in this article to show why it is extremely difficult to expect representatives of missionary religions to engage in productive interreligious dialogue. The article demonstrates how the imperative to convert, which is rooted in a sense of epistemic authority that one holds the best version of truth, precludes interreligious dialogue among religionists. The authors note, on the one hand, that the primary condition for any dialogue is that each of those involved come to the dialogue intellectually humble. (...) On the other hand, the authors note that for missionary religionists to embrace intellectual humility requires a fundamental rethink of their claims of epistemological certainty and final epistemic authority. This implies abandoning the missionary mandate and witnessing built on a sense of intellectual certainty and pride. The authors therefore argue that intellectual humility is a necessary condition for productive interreligious dialogue. Because representatives of missionary religions claim certainty about the knowledge they espouse, what is paraded as interreligious dialogue is largely a myth. It will remain a mere concept that yields little to no tangible result unless these representatives embrace intellectual humility, which is more achievable within a secularist framework.Contribution: This research contributes to the seemingly easy but difficult discourse and practice about interreligious dialogue. It brings to the limelight a more appropriate conception of dialogue in the context of interreligious dialogue, and explains how side-lining that conception empties the predominant practice of interreligous dialogue. This contribution is useful to HTS, which focuses on theological and religious studies, as well as critical study of religions. (shrink)

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

Many scientists and doctors hope that affordable genome sequencing will lead to more personalized medical care and improve public health in ways that will benefit children, families, and society more broadly. One hope in particular is that all newborns could be sequenced at birth, thereby setting the stage for a lifetime of medical care and self‐directed preventive actions tailored to each child's genome. Indeed, commentators often suggest that universal genome sequencing is inevitable. Such optimism can come with the presumption that (...) discussing the potential limits, cost, and downsides of widespread application of genomic technologies is pointless, excessively pessimistic, or overly cautious. We disagree. Given the pragmatic challenges associated with determining what sequencing data mean for the health of individuals, the economic costs associated with interpreting and acting on such data, and the psychosocial costs of predicting one's own or one's child's future life plans based on uncertain testing results, we think this hope and optimism deserve to be tempered.In the analysis that follows, we distinguish between two reasons for using sequencing: to diagnose individual infants who have been identified as sick and to screen populations of infants who appear to be healthy. We also distinguish among three contexts in which sequencing for either diagnosis or screening could be deployed: in clinical medicine, in public health programs, and as a direct‐to‐consumer service. Each of these contexts comes with different professional norms, policy considerations, and public expectations. Finally, we distinguish between two main types of genome sequencing: targeted sequencing, where only specific genes are sequenced or analyzed, and whole‐exome or whole‐genome sequencing, where all the DNA or all the coding segments of all genes are sequenced and analyzed.In a symptomatic newborn, targeted or genome‐wide sequencing can help guide other tests for diagnosis or for specific treatment that is urgently needed. Clinicians use the infant's symptoms (or phenotype) to interrogate the sequencing data. These same complexities and uncertainties, however, limit the usefulness of genome‐wide sequencing as a population screening tool. While we recognize considerable benefit in using targeted sequencing to screen for or detect specific conditions that meet the criteria for inclusion in newborn screening panels, use of genome‐wide sequencing as a sole screening tool for newborns is at best premature. We conclude that sequencing technology can be beneficially used in newborns when that use is nuanced and attentive to context. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Two Poems JOSEPHINE BALMER The House Opposite (Walbrook, London, 78 CE) Give this note to the cooper Junius, just opposite the house of Catullus... —Bloomberg Writing Tablets, 14 I unpack my treasures of Syrian glass, plates sourced from the slopes of Vesuvius. The walls I paint with frail shoots of grass and a poppy—my own hidden message for those who know the poet, my namesake: a flower fallen (...) at the meadow’s edge... I had pictured myself as a pioneer composing stark, startling, northern poems as fêted (one day) as my famed forebear. Besides, I’d been priced out of Rome. Yet each word I write I later delete. I watch the starlings rising up at dusk above the teeming, cloud-fogged streets like a simile slipping out of grasp. I hear the drunken Rhenish equites chant their taproom verse, swilled in vomit our bleak reward for six months’ back pay. My voice still clogs with Londinium clay. All I am here is the house opposite the cooper, two doors from the brewer. The only lines that come, come in error and for them: barrels, bills, more calls for beer. arion 27.2 fall 2019 Catullus the Slave (Walbrook, London, 79 CE) To Catullus the slave of Romanius Faustinus: 2000 units, 65 denarii [lines struck through] —Bloomberg Writing Tablets, 70 Six months on, the ice kicked in. My page was frost-white, its lines still frozen. By the following year I had given up, sold everything— volcanic crockery to the cooper, ink-smudged glass to the brewer who was branching out to wine. When even that was not enough I sold myself to Romanius Faustinus, a scrawny Gallic works contractor (a literary man, he said, was worth more than most). I did his books. I counted bricks, tessera for mosaics shifting back into the face of Orpheus, accounts closed, nothing outstanding. I learnt silence where once I spoke— he owned the air, he owned my breath— so I mouthed the verse I used to quote, the finest Catullus (snr) had written: you pea-brain, hairy-legged hick whose farts are your best feature... And concurred re bastard Caesar: why did he ever eye up Britain, that cursed place, ugly and remote? two poems 136... (shrink)

Subject to the ruthless accountancy of the neoliberal university, the humanities are under increasing pressure to make a case for why they count. This article focuses on how the field of li...

Was ist Musik? Diese musikphilosophische Fragestel-lung bildet den Ausgangspunkt von Josephine Geislers phänomenologischer Untersuchung, die einen wichtigen Beitrag zur anthropologischen Grundlagenforschung liefert. Geisler greift in diesem Zusammenhang nicht nur auf die Phänomenologie der Tonwahrnehmung Husserls zurück, sondern auch auf Helmuth Plessners ästhesiologische Schriften, die bisher kaum rezipiert wurden. Auch Günther Anders' musikphänomenologische Habilitationsschrift - noch nicht veröffentlicht und daher wenig bekannt - dient als theoretische Grundlage. Anhand dieser drei Autoren legt die Arbeit mit den Kategorien Zeitlichkeit, Leiblichkeit und Gestimmtheit (...) anthropologische Konstanten des Verhältnisses Mensch-Musik frei und verweist damit auf den normativen Eigensinn des besonderen Wahrnehmungsereignisses Musik. (shrink)

The theoretical value of talking to the media isn’t hard to appreciate. Who doesn’t want to shape the public conversation, whether to make it more nuanced and reasoned or to bring injustice and wrongdoing to light? Issues you’ve studied are in the news and you get to be the expert, pointing out what’s wrong, or right, or offering another way of thinking about a difficult question. If you’re lucky, you get your name in print—and in a publication your friends and (...) family actually read. But it can also be intimidating. I used to feel like the hapless witness about to be cross-examined by the wily attorney. I’d heard about the twenty-four-hour news cycle and the push to appeal to the lowest common denominator.... (shrink)

Laffin, Josephine The archbishop of Adelaide, it must be acknowledged, did not play a prominent role at Vatican II. Matthew Beovich never gave a speech in the aula, the Council 'hall' inside St Peter's Basilica, nor did he prepare a written submission. At first glance, his seemingly minimal participation reinforces the damning judgment of Patrick O'Farrell that members of the Australian hierarchy were 'frequently uncomprehending and even resistant to the spirit of change'. With this from the doyen of Catholic (...) historians in Australia in the late twentieth century, it is not surprising that Ian Breward concluded in his survey of Australian religious history: 'Most Australian bishops were bemused observers of a process which shattered their convictions about the uniformity of the Roman Catholic Church. Australian contributions to Council debates were few. The pragmatism and traditionalism of the Australian Church stood nakedly exposed'. (shrink)